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AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS

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abstract
The purpose of this study was to investigate the regulation of SAMHD1 and its relation to nucleotide metabolism and cell cycle progression. Phosphorylation of SAMHD1 is the most extensively documented means of regulation. While questions still remain regarding regulation of SAMHD1 by phosphorylation, this work investigates an alternative mechanism of regulation. A major signaling pathway that has not been investigated with regards to SAMHD1 regulation is redox biology. Redox biology is emerging as a central regulator in myriad cellular processes including cell cycle progression, cellular metabolism, and cell signaling. Given the role that nucleotide metabolism plays in these processes, this study was undertaken to test the hypothesis that SAMHD1 is a redox regulated enzyme and that redox signaling is important for modulating SAMHD1 activity in vivo.
subject
Aicardi-Goutieres
cell cycle
deoxynucleotide triphosphate
HIV
Redox
SAMDH1
contributor
Mauney, Christopher Holbrook (author)
Hollis, Thomas J (committee chair)
Alexander, Rebecca (committee member)
Lowther, W. Todd (committee member)
Lyles, Doug (committee member)
Ornelles, David (committee member)
Perrino, Fred (committee member)
date
2017-06-15T08:36:12Z (accessioned)
2019-06-14T08:30:14Z (available)
2017 (issued)
degree
Biochemistry and Molecular Biology (discipline)
embargo
2019-06-14 (terms)
identifier
http://hdl.handle.net/10339/82241 (uri)
language
en (iso)
publisher
Wake Forest University
title
AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS
type
Dissertation

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