Item Details

title

UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY

author

Poole, Thomas

abstract

Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation.

subject

Click

Dimedone

Peroxiredoxin

Signaling

Sulfenic Acid

Thiol

contributor

King, Stephen Bruce (committee chair)

Poole, Leslie B. (committee member)

Dos Santos, Patricia C. (committee member)

Jones, Paul B. (committee member)

Welker, Mark E. (committee member)

date

2017-06-15T08:36:18Z (accessioned)

2018-06-14T08:30:13Z (available)

2017 (issued)

degree

Chemistry (discipline)

embargo

2018-06-14 (terms)

identifier

http://hdl.handle.net/10339/82253 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation