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UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY

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abstract
Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation.
subject
Click
Dimedone
Peroxiredoxin
Signaling
Sulfenic Acid
Thiol
contributor
Poole, Thomas (author)
King, Stephen Bruce (committee chair)
Poole, Leslie B. (committee member)
Dos Santos, Patricia C. (committee member)
Jones, Paul B. (committee member)
Welker, Mark E. (committee member)
date
2017-06-15T08:36:18Z (accessioned)
2018-06-14T08:30:13Z (available)
2017 (issued)
degree
Chemistry (discipline)
embargo
2018-06-14 (terms)
identifier
http://hdl.handle.net/10339/82253 (uri)
language
en (iso)
publisher
Wake Forest University
title
UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY
type
Dissertation

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