Item Details

title

TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING

author

Kengla, Carlos Vinicio

abstract

Tissue Engineering and Regenerative Medicine fields of life science and engineering strive to address medical challenges to human flourishing. Innovative research has led to many advances in the past two centuries with regards to treatment of orthopaedic trauma, but better options for treatment of bone injuries resulting in bony defects are still needed. Autologous bone grafts remain the standard treatment for segmental defects and non-unions. Engineered bone graft substitutes have failed to promote sufficient bone formation in large defects. The work presented here aims to prove a new platform for engineering bone tissue using 3D bioprinting strategy has the capability of combining multiple clinically relevant biomaterials in biomimetic designs to improve outcomes for engineered bone graft substitutes. The aim of these explorations is to move outcomes toward clinical use and patient benefit.

subject

bioprinting

bone

bone graft substitute

personalized medicine

tissue engineering

contributor

Lee, Sang Jin (committee chair)

Downs, Brian W (committee member)

Yoo, James J (committee member)

Skardal, Aleksander (committee member)

Goldstein, Aaron S (committee member)

date

2017-08-22T08:35:22Z (accessioned)

2018-02-21T09:30:12Z (available)

2017 (issued)

degree

Biomedical Engineering (discipline)

embargo

2018-02-21 (terms)

identifier

http://hdl.handle.net/10339/86336 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation