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MOLECULAR ANALYSIS OF HYALURONIC ACID (HA) USING SOLID-STATE NANOPORES

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title
MOLECULAR ANALYSIS OF HYALURONIC ACID (HA) USING SOLID-STATE NANOPORES
author
Rivas Duarte, Felipe
abstract
Hyaluronic acid (HA; hyaluronan) has emerged as a powerful indicator for a range of diseases and physiological conditions, including cancer, osteoarthritis, and wound healing after injury. Evidence has shown that low molecular weight HA is pro-inflammatory while high molecular weight HA is anti-inflammatory, suggesting the potential importance of HA size as an independent biomarker. However, current methods to measure HA are time consuming, rarely distinguish HA by molecular weight and are not easily integrated in the clinical setting. Thus, there is a need for improved HA detection and quantification methods that can address this need.
subject
Biosensor
Hyaluronic acid
Molecular weight
Osteoarthritis
Solid-state nanopore
Translational
contributor
Rahbar, Elaheh (committee chair)
Rahbar, Elaheh (committee member)
Hall, Adam R (committee member)
Skardal, Aleksander (committee member)
date
2017-08-22T08:35:24Z (accessioned)
2019-08-21T08:30:13Z (available)
2017 (issued)
degree
Biomedical Engineering (discipline)
embargo
2019-08-21 (terms)
identifier
http://hdl.handle.net/10339/86345 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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