Item Details

title

MOLECULAR ANALYSIS OF HYALURONIC ACID (HA) USING SOLID-STATE NANOPORES

author

Rivas Duarte, Felipe

abstract

Hyaluronic acid (HA; hyaluronan) has emerged as a powerful indicator for a range of diseases and physiological conditions, including cancer, osteoarthritis, and wound healing after injury. Evidence has shown that low molecular weight HA is pro-inflammatory while high molecular weight HA is anti-inflammatory, suggesting the potential importance of HA size as an independent biomarker. However, current methods to measure HA are time consuming, rarely distinguish HA by molecular weight and are not easily integrated in the clinical setting. Thus, there is a need for improved HA detection and quantification methods that can address this need.

subject

Biosensor

Hyaluronic acid

Molecular weight

Osteoarthritis

Solid-state nanopore

Translational

contributor

Rahbar, Elaheh (committee chair)

Rahbar, Elaheh (committee member)

Hall, Adam R (committee member)

Skardal, Aleksander (committee member)

date

2017-08-22T08:35:24Z (accessioned)

2019-08-21T08:30:13Z (available)

2017 (issued)

degree

Biomedical Engineering (discipline)

embargo

2019-08-21 (terms)

identifier

http://hdl.handle.net/10339/86345 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis