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IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS

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abstract
Amplitude - modulated 27.12 MHz radiofrequency electromagnetic fields (AM RF EMF) delivered via a spoon - shaped antenna placed on the patient’s tongue results in shrinkage of the primary and metastatic tumors in patients with advanced hepatocellular carcinoma (HCC). The mechanism by which AM RF EMF have direct antiproliferative eff ect ca ncer cells is largely unknown. In order to deduce the unknown mechanism of action w e have a ssessed the Specific Absorption Rate (SAR) level and dis tribution inside the human body . Additionally, we performed various i n vitro and in vivo experiments that were exposed to HCC - specific AM RF EMF using systems replicating human exposure levels and treatment duration . The resulting data provided new insights into the mechanism of action of a novel systemic therapy. Therefore, this dissertation will show that HCC - specific AM RF EMF’s antiproliferative effects are mediated by Ca 2+ influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key functional role for Ca v 3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC - specific AM RF EMF.
subject
Amplitude-modulated
Cav 3.2
electromagnetic fields
Hepatocellular Carcinoma
Radiofrequency
T-type voltage gated calcium channels
contributor
Jimenez, Hugo (author)
Pasche, Boris C (committee chair)
Lesser, Glenn (committee member)
Blackman, Carl F. (committee member)
Debinski, Waldemar (committee member)
Singh, Ravi (committee member)
date
2018-05-24T08:35:44Z (accessioned)
2020-05-23T08:30:19Z (available)
2018 (issued)
degree
Cancer Biology (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/90681 (uri)
language
en (iso)
publisher
Wake Forest University
title
IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
type
Dissertation

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