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The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding

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abstract
Overconsumption, or eating beyond the point of homeostasis, is a key feature in the development of obesity. Although people are consuming beyond the point of homeostasis, they are not consuming constantly or indefinitely. Thus, there is likely a mechanism that acts to terminate periods of food intake at some point beyond satiation and prior to aversion, or the negative effects of extreme excess (nausea, bloating, etc.). The purpose of the present study was to assess the lateral habenula as a candidate region, due to its connectivity to midbrain reward circuitry, sensitivity to metabolic signaling, and pronounced role in drug-related motivated behaviors. Here I report that inactivation of the LHb attenuated feeding of deprived animals on a sweetened-fat diet, though impacted neither sated animals nor animals consuming a standard chow diet. However, inactivation did produce a consistent increase in locomotor activity across all conditions and in both experimental groups. Furthermore, mu-opioid stimulation increased feeding on standard chow, but decreased intake of the sweetened-fat diet. Taken together, these results suggest an important, if nuanced role, for the LHb in motivated behavior.
subject
baclofen-muscimol
lateral habenula
contributor
Carlson, Hannah Nicole (author)
Pratt, Wayne E (committee chair)
Masicampo, Melissa L (committee member)
Fahrbach, Susan E (committee member)
date
2018-05-24T08:35:54Z (accessioned)
2020-05-23T08:30:19Z (available)
2018 (issued)
degree
Psychology (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/90696 (uri)
language
en (iso)
publisher
Wake Forest University
title
The Behavioral Effects of Temporary Inactivation of the Lateral Habenula on Free Feeding
type
Thesis

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