Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
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Item Details
- title
- Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
- author
- Andrews, Rachel Nicole
- abstract
- Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain.
- subject
- ionizing radiation
- macaque
- radiation-induced brain injury
- radiotherapy
- whole brain irradiation
- contributor
- Cline, J. Mark (committee chair)
- Metheny-Barlow, Linda J (committee member)
- Neigh, Gretchen (committee member)
- O'Banion, M. Kerry (committee member)
- Peiffer, Ann M (committee member)
- date
- 2018-05-24T08:36:04Z (accessioned)
- 2020-05-23T08:30:16Z (available)
- 2018 (issued)
- degree
- Molecular Medicine and Translational Science (discipline)
- embargo
- 2020-05-23 (terms)
- identifier
- http://hdl.handle.net/10339/90713 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation