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Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling

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abstract
Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain.
subject
ionizing radiation
macaque
radiation-induced brain injury
radiotherapy
whole brain irradiation
contributor
Andrews, Rachel Nicole (author)
Cline, J. Mark (committee chair)
Metheny-Barlow, Linda J (committee member)
Neigh, Gretchen (committee member)
O'Banion, M. Kerry (committee member)
Peiffer, Ann M (committee member)
date
2018-05-24T08:36:04Z (accessioned)
2020-05-23T08:30:16Z (available)
2018 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/90713 (uri)
language
en (iso)
publisher
Wake Forest University
title
Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
type
Dissertation

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