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Nitrate Consumption and Physical Function in ICU Patients

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abstract
Ingested dietary nitrate which is converted to nit rite and then to nitric oxide has been shown to be ergogenic in clinical populations. The conversion of nitrate to nitrite is facilitated by bacteria in the oral cavity. PURPOSE: 1) to examine nitrite levels following nitrate ingestion in ICU patients receiving antibiotics, and 2) to determine if nitrate ingestion improved physical function at hospital discharge. METHODS: ICU patients (n=22) were randomized to receive eith er nitrate rich (400 mg) or nitrate depleted beetroot juice (placebo) for the duration of their hospital stay. Plasma nitrate and nitrite were measured prior to and three hours post consumption on the first dose. Physical function was measured at hospita l discharge using the Short Physical Performance Battery. RESULTS: In the nitrate rich beetroot juice group, nitrate and nitrite increased from pre (26.0 ± 7.0 μM and 141.0 ± 10.1 nM, respectively) to post (245.2 ± 52.1 μM and 284.2 ± 50.3 nM, respectivel y) consumption. Neither nitrate nor nitrite increased significantly from pre to post consumption in the nitrate depleted beetroot juice group. Short Physical Performance Battery scores at hospital discharge were not significantly different between the nitr ate rich beetroot juice group (2.0 ± 0.9) and the placebo group (3.5 ± 0.9). CONCLUSION: Nitrate supplementation in the form of beetroot juice was effective at increasing plasma nitrate and nitrite levels in ICU patients even in the presence of antibiotic administration; however, physical function at hospital discharge v did not appe ar impacted by nitrate supplementation. Future studies should examine physical function beyond hospital discharge and pair nitrate supplementation with an early exercise intervention.
subject
Beetroot
Function
ICU
Nitrate
Nitrite
Physical
contributor
Heinrich, Timothy Michael (author)
Berry, Michael J (committee chair)
Miller, Gary D (committee member)
Bakhru, Rita N (committee member)
date
2018-05-24T08:36:08Z (accessioned)
2020-05-23T08:30:18Z (available)
2018 (issued)
degree
Health and Exercise Science (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/90724 (uri)
language
en (iso)
publisher
Wake Forest University
title
Nitrate Consumption and Physical Function in ICU Patients
type
Thesis

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