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EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS

Electronic Theses and Dissertations

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abstract
Chronic intermittent ethanol (CIE) treatment is known to produce changes in synaptic plasticity and excitability in animal models. Data from our lab suggests that withdrawal from CIE exposure induces an increase in anxiety-like behavior and an increase in hippocampal excitability in male rats. We also found that this increase in excitability is largely restricted to the ventral domain of the hippocampus (VHC). Although relatively few studies have examined the effects of CIE in females, emerging evidence suggests that they may be less sensitive to CIE treatment. Here we sought to test the hypotheses that CIE would have less effect on negative affective behaviors in female rats and little or no increase in hippocampal excitability, with any increase in excitability being greater in the VHC than the dorsal hippocampus (DHC). Adult female Long Evans rats underwent a 10-12 day CIE protocol, followed by 24-48 hours of withdrawal. At which point electrophysiological or behavioral testing was conducted. Surprisingly, CIE led to an overall decrease in hippocampal excitability, and this change was largely restricted to the VHC, with a modest increase in excitably in the DHC. CIE led to an increase in anxiety-like behavior on the alley test and an increase in depressive-like behavior on the forced swim test. The initial findings from these ongoing studies suggest that there may be profound sex differences associated with some of the maladaptive behavioral and neurophysiological adaptations promoted by CIE. Additional studies will be needed to unravel the neurobiological mechanisms associated with these sexually dimorphic alterations.
subject
contributor
Morgan, James (author)
Weiner, Jeff L (committee chair)
Czoty, Paul W (committee member)
date
2018-05-24T08:36:13Z (accessioned)
2019-05-23T08:30:11Z (available)
2018 (issued)
degree
Biomedical Science – MS (discipline)
embargo
2019-05-23 (terms)
identifier
http://hdl.handle.net/10339/90737 (uri)
language
en (iso)
publisher
Wake Forest University
title
EXAMINING SEX DIFFERENCES IN NEUROBIOLOGICAL AND BEHAVIORAL CHANGES INDUCED BY CHRONIC INTERMITTENT ETHANOL VAPOR EXPOSURE IN LONG EVANS RATS
type
Thesis

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