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TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO

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abstract
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the fourth most common cancer in the United States. When CRC disseminates into the abdominal cavity, there can be hundreds, if not thousands, of small tumors infiltrating the surfaces of organs, making it extremely difficult to treat by conventional methods. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in combination with cytoreductive surgery (CRS) has improved the 5-year survival rate of late-stage CRC patients from 12% to 51%. However, the survival rates of these patients have stagnated, which emphasizes the need for more innovative approaches to improve patient survival outcomes.
subject
Colorectal Cancer
HIPEC
Photothermal Therapy
Polymer Nanoparticles
Theranostic
Tissue Phantoms
contributor
McCabe, Eleanor (author)
Levi-Polyachenko, Nicole H (committee chair)
Stewart, John H (committee member)
Wagner, William D (committee member)
Seeds, Michael C (committee member)
Mohs, Aaron M (committee member)
date
2018-05-24T08:36:13Z (accessioned)
2020-05-23T08:30:16Z (available)
2018 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/90738 (uri)
language
en (iso)
publisher
Wake Forest University
title
TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO
type
Dissertation

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