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TREX1 DNASE ACTIVITY IS REGULATED BY PHOSPHORYLATION AND MACROPHAGES LACKING TREX1 HAVE IMPAIRED EFFEREOCYTOSIS

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abstract
TREX1 is a 3′ to 5′ exonuclease found in metazoan cells. TREX1 acts on both ssDNA and dsDNA and functions to prevent adverse immune activation by degrading cytosolic nucleic acids that would otherwise activate DNA sensors resulting in interferon production. Mutations in TREX1 cause multifactoral, systemic autoimmune diseases. Lack of TREX1 activity is not the only means of causing disease. Patients with fully active TREX1 who have mutations or frameshifts in the C-terminal region develop autoimmune disease presumably by disrupting protein-protein interactions or proper localization vital for normal cell biology. Understanding this multifaceted role of TREX1 in cell biology requires a thorough investigation of the regulation and involvement of TREX1 in nucleotide metabolism.
subject
DNA
exonuclease
macrophage
nucleic acid
phosphorylation
TREX1
contributor
Davis, Ryan Richard (author)
Hollis, Thomas (committee chair)
Perrino, Fred W (committee member)
Daniel, Larry W (committee member)
Poole, Leslie B (committee member)
date
2018-08-23T08:35:25Z (accessioned)
2019-08-22T08:30:14Z (available)
2018 (issued)
degree
Biochemistry and Molecular Biology (discipline)
embargo
2019-08-22 (terms)
identifier
http://hdl.handle.net/10339/92370 (uri)
language
en (iso)
publisher
Wake Forest University
title
TREX1 DNASE ACTIVITY IS REGULATED BY PHOSPHORYLATION AND MACROPHAGES LACKING TREX1 HAVE IMPAIRED EFFEREOCYTOSIS
type
Dissertation

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