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FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING

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abstract
Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting
subject
contributor
Warner, Harleigh Jane (author)
Wagner, William D (committee chair)
Goldstein, Aaron (committee member)
Jordan, James (committee member)
Whittington, Abby (committee member)
Skardal, Aleksander (committee member)
date
2018-08-23T08:35:38Z (accessioned)
2019-08-22T08:30:13Z (available)
2018 (issued)
degree
Biomedical Engineering (discipline)
embargo
2019-08-22 (terms)
identifier
http://hdl.handle.net/10339/92380 (uri)
language
en (iso)
publisher
Wake Forest University
title
FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING
type
Dissertation

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