Item Details

title

FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING

author

Warner, Harleigh Jane

abstract

Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting

contributor

Wagner, William D (committee chair)

Goldstein, Aaron (committee member)

Jordan, James (committee member)

Whittington, Abby (committee member)

Skardal, Aleksander (committee member)

date

2018-08-23T08:35:38Z (accessioned)

2019-08-22T08:30:13Z (available)

2018 (issued)

degree

Biomedical Engineering (discipline)

embargo

2019-08-22 (terms)

identifier

http://hdl.handle.net/10339/92380 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation