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AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA

Electronic Theses and Dissertations

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title
AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA
author
Ghiraldeli, Lais Pereira
abstract
Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow characterized by poor prognosis and resistance to chemotherapy. The way in which cancerous cells are able to metabolically adapt to various physiological and metabolic stressors allows them to thrive and proliferate. A leading candidate to coordinate this oxidative metabolic shift is the AMP-activated protein kinase (AMPK).
subject
AML
AMPK
Chemotherapy
Chemotherapy Resistance
Resistance
contributor
Pardee, Timothy (committee chair)
Kerr, Bethany (committee member)
Smith, Thomas (committee member)
date
2018-08-23T08:35:40Z (accessioned)
2020-08-22T08:30:14Z (available)
2018 (issued)
degree
Cancer Biology (discipline)
embargo
2020-08-22 (terms)
identifier
http://hdl.handle.net/10339/92387 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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