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Investigation of Adiposity Phenotypes in AA Associated With GALNT10 & Related Pathway Genes

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abstract
The overall goal of this project is to verify previous findings in the GALNT10 region and to expand our knowledge of this locus via genomic association studies in obesity-related traits, comparison to expression quantitative trait loci (eQTL) data, and a mouse knockout model, in addition to furthering our knowledge of genes in the pathway in which GALNT10 acts. Previously, genome-wide association studies in African Americans (AA) have identified common variants upstream of GALNT10 locus for association with body mass index (BMI). These studies encompassed a small number of variants upstream of GALNT10 that were common, noncoding variants, as is typically seen in GWAS studies.
subject
contributor
Stromberg, Mary (author)
Bowden, Donald W (committee chair)
Das, Swapan K (committee member)
Howard, Timothy D (committee member)
Parks, John P (committee member)
date
2019-01-11T09:35:17Z (accessioned)
2019-01-11T09:35:17Z (available)
2018 (issued)
degree
Molecular Genetics & Genomics (discipline)
identifier
http://hdl.handle.net/10339/93050 (uri)
language
en (iso)
publisher
Wake Forest University
title
Investigation of Adiposity Phenotypes in AA Associated With GALNT10 & Related Pathway Genes
type
Dissertation

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