Item Details

title

Investigation of Adiposity Phenotypes in AA Associated With GALNT10 & Related Pathway Genes

author

Stromberg, Mary

abstract

The overall goal of this project is to verify previous findings in the GALNT10 region and to expand our knowledge of this locus via genomic association studies in obesity-related traits, comparison to expression quantitative trait loci (eQTL) data, and a mouse knockout model, in addition to furthering our knowledge of genes in the pathway in which GALNT10 acts. Previously, genome-wide association studies in African Americans (AA) have identified common variants upstream of GALNT10 locus for association with body mass index (BMI). These studies encompassed a small number of variants upstream of GALNT10 that were common, noncoding variants, as is typically seen in GWAS studies.

contributor

Bowden, Donald W (committee chair)

Das, Swapan K (committee member)

Howard, Timothy D (committee member)

Parks, John P (committee member)

date

2019-01-11T09:35:17Z (accessioned)

2019-01-11T09:35:17Z (available)

2018 (issued)

degree

Molecular Genetics & Genomics (discipline)

identifier

http://hdl.handle.net/10339/93050 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation