Item Details

abstract

Hypertension affects over 50% of adults in the United States and is a risk factor for cardiac hypertrophy, stroke, myocardial infarction, and heart failure. If high blood pressure is untreated, damage to the myocardium and vasculature occurs, resulting in pathological fibrosis, hypertrophy, and inflammation. Polyphenols have antioxidant and anti-inflammatory properties and are beneficial against cardiovascular risk. Muscadine grapes are native to the Southeastern US and their skins and seeds are abundant in polyphenols including ellagic acid, gallic acid, and catechins. Previous studies demonstrated that muscadine grapes reduce cell proliferation and decrease inflammation. In these studies, we investigated the effects of a muscadine grape extract (MGE) on angiotensin II (Ang II)-induced hypertension and the resulting cardiac and vascular damage.

subject

cardiac

fibrosis

grape

hypertension

polyphenol

contributor

Patil, Pooja (author)

Tallant, Elisabeth A (committee chair)

Jordan, James E (committee member)

Criswell, Tracy L (committee member)

Varagic, Jasmina (committee member)

date

2019-05-24T08:35:29Z (accessioned)

2020-05-23T08:30:17Z (available)

2019 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2020-05-23 (terms)

identifier

http://hdl.handle.net/10339/93905 (uri)

language

en (iso)

publisher

Wake Forest University

title

A MUSCADINE GRAPE EXTRACT PREVENTS HYPERTENSION-INDUCED CARDIAC AND VASCULAR DAMAGE IN ASSOCIATION WITH ANTI-FIBROTIC AND ANTIOXIDANT MECHANISMS

type

Dissertation