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A MUSCADINE GRAPE EXTRACT PREVENTS HYPERTENSION-INDUCED CARDIAC AND VASCULAR DAMAGE IN ASSOCIATION WITH ANTI-FIBROTIC AND ANTIOXIDANT MECHANISMS

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abstract
Hypertension affects over 50% of adults in the United States and is a risk factor for cardiac hypertrophy, stroke, myocardial infarction, and heart failure. If high blood pressure is untreated, damage to the myocardium and vasculature occurs, resulting in pathological fibrosis, hypertrophy, and inflammation. Polyphenols have antioxidant and anti-inflammatory properties and are beneficial against cardiovascular risk. Muscadine grapes are native to the Southeastern US and their skins and seeds are abundant in polyphenols including ellagic acid, gallic acid, and catechins. Previous studies demonstrated that muscadine grapes reduce cell proliferation and decrease inflammation. In these studies, we investigated the effects of a muscadine grape extract (MGE) on angiotensin II (Ang II)-induced hypertension and the resulting cardiac and vascular damage.
subject
cardiac
fibrosis
grape
hypertension
polyphenol
contributor
Patil, Pooja (author)
Tallant, Elisabeth A (committee chair)
Jordan, James E (committee member)
Criswell, Tracy L (committee member)
Varagic, Jasmina (committee member)
date
2019-05-24T08:35:29Z (accessioned)
2020-05-23T08:30:17Z (available)
2019 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/93905 (uri)
language
en (iso)
publisher
Wake Forest University
title
A MUSCADINE GRAPE EXTRACT PREVENTS HYPERTENSION-INDUCED CARDIAC AND VASCULAR DAMAGE IN ASSOCIATION WITH ANTI-FIBROTIC AND ANTIOXIDANT MECHANISMS
type
Dissertation

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