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Implications of Point of Care Testing (POC) for Identification of Prediabetes in a Randomized Controlled Trial

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abstract
Efficiently identifying individuals at high risk of diabetes is a priority for examining implementation methods to increase access, reach, and scalability of diabetes prevention programs (DPPs). The purpose of this study was to assess the ability of point of care (POC) device to identify participants with prediabetes for inclusion in an RCT designed to test the impact a digital DPP platform on body weight and HbA1c. Initially, participants were screened for evidence of impaired glucose metabolism via POC device. However, preliminary analyses discovered lack of correspondence between POC and lab assay methods to assess HbA1c leading to changes in the screening protocol. Analyses revealed that 116 randomized participants had a lab assay HbA1c outside of the eligibility criterion. Additionally, the sample obtained via POC screening (pre-amendment) had significantly lower mean HbA1c as compared to the sample screened using lab assay (post-amendment). The post-amendment sample was significantly older, but had lower blood pressure and body weight than the pre-amendment sample. Rate of recruitment was not affected by the change in screening protocol. The results of the present study indicate that use of POC to identify a prediabetic sample may be problematic; however, future research with higher quality POC device is warranted.
subject
Diabetes Prevention
HbA1c
Point of Care
Randomized Controlled Trial
Scalability
contributor
Boggs, Ashley Elizabeth (author)
Katula, Jeffrey A (committee chair)
Miller, Gary D (committee member)
date
2019-05-24T08:35:42Z (accessioned)
2020-05-23T08:30:19Z (available)
2019 (issued)
degree
Health and Exercise Science (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/93941 (uri)
language
en (iso)
publisher
Wake Forest University
title
Implications of Point of Care Testing (POC) for Identification of Prediabetes in a Randomized Controlled Trial
type
Thesis

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