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Immunomodulation as a Potential Therapeutic Strategy Following Spinal Cord Contusion Injury to Limit Tissue Damage and Improve Functional Recovery

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abstract
Spinal cord injuries (SCI) are a debilitating neurological trauma with about 500,000 new cases occuring worldwide every year. Outside of decompression surgery and physical therapy, there are no effective treatments currently available leaving patients with severe neurological deficits. A wide range of molecular and cellular events occur in response to injury resulting in a sustained inflammatory state that causes further tissue loss known as the secondary injury. It is commonly thought that manipulating the severity and timing of the inflammatory responses may limit the secondary injury and ultimately prevent tissue damage associated functional losses.
subject
Immunomodulation
Macrophage Polarization
Neurotrauma
Spinal Cord Injury
contributor
Zabarsky, Zachary (author)
Smith, Thomas L (committee chair)
Peters, Christopher (committee member)
Almeida-Porada, Graca (committee member)
Howlett, Allyn (committee member)
Li, Zhongyu (committee member)
date
2019-05-24T08:35:44Z (accessioned)
2019-11-23T09:30:26Z (available)
2019 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2019-11-23 (terms)
identifier
http://hdl.handle.net/10339/93955 (uri)
language
en (iso)
publisher
Wake Forest University
title
Immunomodulation as a Potential Therapeutic Strategy Following Spinal Cord Contusion Injury to Limit Tissue Damage and Improve Functional Recovery
type
Dissertation

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