Immunomodulation as a Potential Therapeutic Strategy Following Spinal Cord Contusion Injury to Limit Tissue Damage and Improve Functional Recovery
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- abstract
- Spinal cord injuries (SCI) are a debilitating neurological trauma with about 500,000 new cases occuring worldwide every year. Outside of decompression surgery and physical therapy, there are no effective treatments currently available leaving patients with severe neurological deficits. A wide range of molecular and cellular events occur in response to injury resulting in a sustained inflammatory state that causes further tissue loss known as the secondary injury. It is commonly thought that manipulating the severity and timing of the inflammatory responses may limit the secondary injury and ultimately prevent tissue damage associated functional losses.
- subject
- Immunomodulation
- Macrophage Polarization
- Neurotrauma
- Spinal Cord Injury
- contributor
- Smith, Thomas L (committee chair)
- Peters, Christopher (committee member)
- Almeida-Porada, Graca (committee member)
- Howlett, Allyn (committee member)
- Li, Zhongyu (committee member)
- date
- 2019-05-24T08:35:44Z (accessioned)
- 2019-11-23T09:30:26Z (available)
- 2019 (issued)
- degree
- Physiology and Pharmacology (discipline)
- embargo
- 2019-11-23 (terms)
- identifier
- http://hdl.handle.net/10339/93955 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- Immunomodulation as a Potential Therapeutic Strategy Following Spinal Cord Contusion Injury to Limit Tissue Damage and Improve Functional Recovery
- type
- Dissertation