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EXAMINING THE ROLE OF PREFRONTAL CORTEX AND INSULAR CORTEX PROJECTIONS TO THE BASOLATERAL AMYGDALA IN SYNAPTIC PLASTICITY AND ANXIETY-LIKE BEHAVIOR FOLLOWING WITHDRAWAL FROM CHRONIC ETHANOL EXPOSURE

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abstract
Alcohol use disorder (AUD) is a chronic relapsing brain disease. Increased anxiety during alcohol withdrawal is a characteristic of AUD and commonly contributes to relapse. The basolateral amygdala (BLA) is a brain region that has long been identified as a critical regulator of emotion, including anxiety. The BLA can regulate emotion and behavior through its interactions with other brain regions such as the medial prefrontal cortex (mPFC) and the agranular insular cortex (AIC). BLA afferents arrive through two primary pathways: medially through the stria terminalis (ST) or laterally through the external capsule (EC). Using chronic intermittent ethanol (CIE) exposure, an animal model that reliably produces dependence-like behaviors including increased anxiety-like behavior during withdrawal, we’ve shown that ethanol-induced synaptic alterations in these two pathways are input- and duration-specific. Specifically, ST – BLA synapses undergo presynaptic changes that precede the postsynaptic changes that occur at EC – BLA synapses following withdrawal from CIE. However, it’s unknown if these alterations occur in specific neural circuits.
subject
contributor
McGinnis, Molly Marlene (author)
McCool, Brian A (committee chair)
Martin, Thomas J (committee member)
Chen, Rong (committee member)
Jones, Sara R (committee member)
Stanford, Terrence R (committee member)
date
2019-05-24T08:35:51Z (accessioned)
2020-05-23T08:30:18Z (available)
2019 (issued)
degree
Physiology and Pharmacology (discipline)
embargo
2020-05-23 (terms)
identifier
http://hdl.handle.net/10339/93986 (uri)
language
en (iso)
publisher
Wake Forest University
title
EXAMINING THE ROLE OF PREFRONTAL CORTEX AND INSULAR CORTEX PROJECTIONS TO THE BASOLATERAL AMYGDALA IN SYNAPTIC PLASTICITY AND ANXIETY-LIKE BEHAVIOR FOLLOWING WITHDRAWAL FROM CHRONIC ETHANOL EXPOSURE
type
Dissertation

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