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THE ONCOGENIC TGLI1 TRANSCRIPTION FACTOR IS A NOVEL MEDIATOR OF BREAST CANCER BRAIN METASTASIS

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abstract
Breast cancer brain metastasis (BCBM) occurs in approximately 10-30% of patients with metastatic breast cancer resulting in a median survival of only 6-18 months. This poor survival rate is primarily due to our limited understanding of BCBM biology. The aim of this study is to gain a further understanding of pathways driving BCBM with a key focus on the truncated glioma-associated oncogene homolog 1 (tGLI1, TGLI1) transcription factor discovered in our lab. We have shown that tGLI1 expression is tumor-specific and that it is a gain-of-function GLI1 transcription factor. GLI1 is a zinc-finger transcription factor and the nuclear effector of the sonic hedgehog (Shh) signaling pathway, playing an important role in development and stem cell self-renewal.
subject
Astrocytes
Breast Cancer Stem Cells
Circulating Exosomes
GLI1
MicroRNAs
STAT3
contributor
Sirkisoon, Sherona R (author)
Lo, Hui-Wen (committee chair)
Kucera, Gregory L. (committee member)
Metheny-Barlow, Linda J. (committee member)
Watabe, Kounosuke (committee member)
date
2019-05-24T08:35:53Z (accessioned)
2021-05-23T08:30:12Z (available)
2019 (issued)
degree
Cancer Biology (discipline)
embargo
2021-05-23 (terms)
identifier
http://hdl.handle.net/10339/94003 (uri)
language
en (iso)
publisher
Wake Forest University
title
THE ONCOGENIC TGLI1 TRANSCRIPTION FACTOR IS A NOVEL MEDIATOR OF BREAST CANCER BRAIN METASTASIS
type
Dissertation

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