Item Details

title

THE ONCOGENIC TGLI1 TRANSCRIPTION FACTOR IS A NOVEL MEDIATOR OF BREAST CANCER BRAIN METASTASIS

author

Sirkisoon, Sherona R

abstract

Breast cancer brain metastasis (BCBM) occurs in approximately 10-30% of patients with metastatic breast cancer resulting in a median survival of only 6-18 months. This poor survival rate is primarily due to our limited understanding of BCBM biology. The aim of this study is to gain a further understanding of pathways driving BCBM with a key focus on the truncated glioma-associated oncogene homolog 1 (tGLI1, TGLI1) transcription factor discovered in our lab. We have shown that tGLI1 expression is tumor-specific and that it is a gain-of-function GLI1 transcription factor. GLI1 is a zinc-finger transcription factor and the nuclear effector of the sonic hedgehog (Shh) signaling pathway, playing an important role in development and stem cell self-renewal.

subject

Astrocytes

Breast Cancer Stem Cells

Circulating Exosomes

GLI1

MicroRNAs

STAT3

contributor

Lo, Hui-Wen (committee chair)

Kucera, Gregory L. (committee member)

Metheny-Barlow, Linda J. (committee member)

Watabe, Kounosuke (committee member)

date

2019-05-24T08:35:53Z (accessioned)

2021-05-23T08:30:12Z (available)

2019 (issued)

degree

Cancer Biology (discipline)

embargo

2021-05-23 (terms)

identifier

http://hdl.handle.net/10339/94003 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation