Item Details

title

EXAMINING THE EFFECTS OF DEEP BRAIN STIMULATION ON THE VOICE, SPEECH, AND SWALLOWING OF PATIENTS WITH MOVEMENT DISORDERS

author

Moya-Mendez, Mary Elizabeth

abstract

The purpose of this thesis is to analyze the voice, speech and swallowing outcomes of patients with movement disorders who undergo Deep Brain Stimulation (DBS). We first established the baseline prevalence of patient-reported voice and swallowing symptoms and discovered that patients with PD and APS report the highest prevalence of these symptoms, and report them significantly earlier in the disease process than other movement disorders. Following this, we found that patients with dystonia who receive bilateral GPi DBS report a delayed improvement in voice and speech outcome measures, which may be due to delayed beneficial effects in the neural pathways associated with speech and voice production and control. Finally, we report an improvement in voice outcome measures before and after device programming in patients with ET following VIM DBS. We also report stimulation parameters, namely pulse width and monopolar and bipolar contact settings which were shown to significantly impact the voice and speech outcomes of these patients. VIM and GPi DBS should continue to be explored as potential treatment options for patients with essential vocal tremor and laryngeal dystonia respectively.

subject

Deep Brain Stimulation

Dystonia

Essential Tremor

Parkinson's Disease

Speech

Voice

contributor

Siddiqui, Mustafa S (committee chair)

Madden, Lyndsay L (committee member)

Masicampo, Melissa L (committee member)

date

2019-09-05T08:35:22Z (accessioned)

2019-09-05T08:35:22Z (available)

2019 (issued)

degree

Biomedical Science – MS (discipline)

identifier

http://hdl.handle.net/10339/94311 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis