Item Details

title

MUSCADINE GRAPE EXTRACT AS A THERAPEUTIC FOR TRIPLE NEGATIVE BREAST CANCER

author

Collard, Marianne

abstract

Triple negative breast cancer (TNBC) is an aggressive subtype that comprises 12-17% of breast cancer cases. TNBC has a high propensity to metastasize; about one-third of patients develop metastatic disease within 5 years of diagnosis. Because TNBC lacks expression of the estrogen receptor, progesterone receptor, and overexpression of the human epidermal growth factor receptor 2, there are no targeted treatments available for this patient cohort. Further, compared to other types of breast cancer, the mean patient age is younger, the mean tumor size is larger, and patients are more likely to have invasive tumors at the time of diagnosis. Due to the aggressive nature of TNBC and lack of therapeutic options to prevent metastatic progression, new treatments are urgently needed.

subject

mapk

metastasis

muscadine grape

natural product

nutraceutical

triple negative breast cancer

contributor

Tallant, Elizabeth A (committee chair)

Kerr, Bethany A (committee member)

Lo, Hui-Wen (committee member)

Deep, Gagan (committee member)

date

2019-09-05T08:35:23Z (accessioned)

2020-09-04T08:30:24Z (available)

2019 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2020-09-04 (terms)

identifier

http://hdl.handle.net/10339/94315 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation