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Modeling the Enteric Nervous System in Autism Spectrum Disorder Using Patient Specific Ipsc-Derived Innervated Gastrointestinal Organoids

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title
Modeling the Enteric Nervous System in Autism Spectrum Disorder Using Patient Specific Ipsc-Derived Innervated Gastrointestinal Organoids
author
Leavitt, Dana
abstract
Chronic gastrointestinal symptoms, including hypomotility, are present in approximately 50-70% of individuals with an autism spectrum disorder (ASD) diagnosis. The mechanisms to explain this comorbidity have yet to be worked out. In the central nervous system, abnormal dendritic morphology has been shown to cause irregular neuron connectivity and cortical architecture. We hypothesize that the irregularities seen in the CNS may also present in the enteric neurons that innervate the gastrointestinal tract. Modeling the enteric nervous system may provide important insights regarding the interrelationship between chronic GI symptoms and neurodevelopmental disorders.
subject
Autism Spectrum Disorder
Enteric Nervous System
Gut Brain Axis
iPSC
Organoids
Phelan McDermid Syndrome
contributor
Walker, Stephen (committee chair)
Bishop, Colin (committee member)
Mack, David (committee member)
Schwartz, Marshall (committee member)
date
2019-09-05T08:35:28Z (accessioned)
2019-09-05T08:35:28Z (available)
2019 (issued)
degree
Neuroscience – MS (discipline)
identifier
http://hdl.handle.net/10339/94322 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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