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ASSOCIATIONS AND DIFFERENCES BETWEEN CEREBRAL BLOOD FLOW AND COGNITIVE SCORES IN PARTICIPANTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION AND HEALTHY CONTROLS

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abstract
Heart failure with preserved ejection fraction (HFpEF) is a disease that primarily affects older, obese women. Currently, the only effective treatment for the disease is exercise training and caloric restriction, as shown by Dr. Kitzman and his team here at Wake Forest. Treatments that have been shown to be effective in heart failure with reduced ejection fraction (HFrEF) have mostly been either neutral or negative. In the present study, HFpEF participants undergoing a 20-week diet and exercise intervention were recruited to perform a brain MRI and neuropsychological testing. Healthy controls from another completed study were also recruited for baseline analyses. Primary aims of this study were to determine if there were any cognitive or cerebral blood flow differences (CBF) between the HFpEF participants and healthy controls. The results presented here show that HFpEF participants may have global cognitive deficits when compared to healthy controls. However, there were no significant differences in memory associated cognitive tasks. There were no significant differences in global CBF between the two cohorts of individuals, and also no significant differences in hippocampal CBF between the two cohorts. Our results indicate that our healthy control group may not be neuropsychologically healthy and may not be truly representative to compare to our HFpEF group. Future directions should include adding a truly healthy control group and examining cognitive and CBF differences between baseline and follow-up after the 20- week intervention in the HFpEF group.
subject
cerebral blood flow
cognition
heart failure with preserved ejection fraction
contributor
Williams, Dakota Lane (author)
Hugenschmidt, Christina E (committee chair)
Whitlow, Christopher T (committee member)
Jung, Youngkyoo (committee member)
date
2019-09-05T08:35:29Z (accessioned)
2019 (issued)
degree
Biomedical Science – MS (discipline)
2024-08-15 (liftdate)
embargo
2024-08-15 (terms)
identifier
http://hdl.handle.net/10339/94324 (uri)
language
en (iso)
publisher
Wake Forest University
title
ASSOCIATIONS AND DIFFERENCES BETWEEN CEREBRAL BLOOD FLOW AND COGNITIVE SCORES IN PARTICIPANTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION AND HEALTHY CONTROLS
type
Thesis

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