Item Details

title

INFLAMMATION AND FRACTURE HEALING: A NEW PARADIGM

author

Marquez-Lara, Alejandro J

abstract

Inflammation plays a fundamental role in bone healing. This complex process is regulated by a myriad of cells and inflammatory mediators that create an adequate environment for subsequent stages of the bone healing cascade. Despite this awareness, most of our understanding of the bone healing process derives from experimental animal models that fail to take into consideration the impact of surgical fixation on fracture healing. The ability to apply pre-clinical findings to clinical practice depends on the translational characteristics of a specific model. As such the first part of this body of work is focused on developing and describing a novel translational fracture model that accounts for surgical fixation as a separate and independent event in the fracture healing process.

subject

Animal model

Biomechanical testing

Fracture Healing

Inflammation

NSAID

contributor

Smith, Thomas L. (committee chair)

Smith, Thomas L (committee member)

Hoth, J. Jason (committee member)

Willey, Jeffrey S (committee member)

Jerome, Chistropher P (committee member)

Miller, Anna N (committee member)

date

2019-09-05T08:35:30Z (accessioned)

2019-09-05T08:35:30Z (available)

2019 (issued)

degree

Molecular Medicine and Translational Science (discipline)

identifier

http://hdl.handle.net/10339/94326 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation