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INVESTIGATING THE PROGNOSTIC IMPORTANCE OF BIOELECTRICAL IMPEDANCE STANDARDIZED PHASE ANGLE IN ADULTS TREATED FOR NEWLY DIAGNOSED ACUTE LEUKEMIA

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abstract
We investigated the predictive value of standardized phase angle (SPhA) on 60-day mortality, overall survival (OS), and length of hospital stay (LHS) for adults with acute myelogenous and lymphoblastic leukemia (AML and ALL). Phase angle measurements were taken on day 1 of induction therapy for all patients and again on the day of nadir bone marrow for AML patients only. Measurements were standardized by BMI, gender, and age to calculate the SPhA. The difference between SPhA at nadir bone marrow and day 1 of induction was used to calculate change in SPhA. A cut off of 25th percentile was used to dichotomize SPhA. Cox proportional hazards models were fit for SPhA and change in SPhA as predictors of OS and LHS while logistic regression models were used to assess 60-day mortality. Among 100 patients 88% were AML, 56% were female, and mean age was 59 years. SPhA was associated with 60-day mortality in univariable (OR=5.25; 1.35, 20.40; P=0.02) but not multivariable analysis (OR=3.12; 0.67, 14.48; P=0.15) adjusted for age, creatinine, and cytogenetics. Change in SPhA was associated with OS (HR=1.16; 1.01-1.34; P=0.04) in multivariable analysis. Standardized phase angle is an objective measure that may be used to inform risk stratification.
subject
Body Composition
Leukemia
Nutrition
Phase Angle
Prognostic
contributor
Yates, Samuel Jackson (author)
Pardee, Timothy S (committee chair)
Klepin, Heidi D (committee member)
Tooze, Janet A (committee member)
date
2019-09-05T08:35:30Z (accessioned)
2020-09-04T08:30:19Z (available)
2019 (issued)
degree
Clinical and Population Translational Sciences (discipline)
embargo
2020-09-04 (terms)
identifier
http://hdl.handle.net/10339/94327 (uri)
language
en (iso)
publisher
Wake Forest University
title
INVESTIGATING THE PROGNOSTIC IMPORTANCE OF BIOELECTRICAL IMPEDANCE STANDARDIZED PHASE ANGLE IN ADULTS TREATED FOR NEWLY DIAGNOSED ACUTE LEUKEMIA
type
Thesis

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