Item Details

abstract

Carbon dots (CDs) represent a class of fluorescent nanomaterials that are emerging as important tools in imaging, biosensing, and medicine, due in large part to their biocompatibility, photostability, low toxicity, and reduced cost relative to many organic dyes and inorganic quantum dots. Given the promise of these new nanomaterials, this dissertation aims to deepen our understanding of the nature and applications of CDs, especially in the realm of analytical separations. In particular, the two overarching goals for this work include: (i) to synthesize CDs by facile, “bottom-up” methods and to characterize the resulting materials by spectroscopic and capillary electrophoresis (CE) techniques; and (ii) to develop and optimize CE-based methods that employ CDs as separation mediators for the separation of metallated proteins, such as transferrin (Tf), a small iron transport protein.

subject

Capillary Electrophoresis (CE)

Carbon Dots (CDs)

Fluorescence

Polymer enhanced capillary transient Isotachophoresis (PectI)

Transferrin (Tf)

contributor

Sirkisoon, Leona Ravini (author)

Colyer, Christa L. (committee chair)

Marrs, Glen (committee member)

Hinze, Willie L. (committee member)

Jones, Paul B. (committee member)

King, S. Bruce (committee member)

date

2020-01-08T09:35:20Z (accessioned)

2022-01-07T09:30:16Z (available)

2019 (issued)

degree

Chemistry (discipline)

embargo

2022-01-07 (terms)

identifier

http://hdl.handle.net/10339/95945 (uri)

language

en (iso)

publisher

Wake Forest University

title

CAPILLARY ELECTROPHORESIS-BASED CHARACTERIZATION AND APPLICATIONS OF CARBON DOTS

type

Dissertation