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CAPILLARY ELECTROPHORESIS-BASED CHARACTERIZATION AND APPLICATIONS OF CARBON DOTS

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abstract
Carbon dots (CDs) represent a class of fluorescent nanomaterials that are emerging as important tools in imaging, biosensing, and medicine, due in large part to their biocompatibility, photostability, low toxicity, and reduced cost relative to many organic dyes and inorganic quantum dots. Given the promise of these new nanomaterials, this dissertation aims to deepen our understanding of the nature and applications of CDs, especially in the realm of analytical separations. In particular, the two overarching goals for this work include: (i) to synthesize CDs by facile, “bottom-up” methods and to characterize the resulting materials by spectroscopic and capillary electrophoresis (CE) techniques; and (ii) to develop and optimize CE-based methods that employ CDs as separation mediators for the separation of metallated proteins, such as transferrin (Tf), a small iron transport protein.
subject
Capillary Electrophoresis (CE)
Carbon Dots (CDs)
Fluorescence
Polymer enhanced capillary transient Isotachophoresis (PectI)
Transferrin (Tf)
contributor
Sirkisoon, Leona Ravini (author)
Colyer, Christa L. (committee chair)
Marrs, Glen (committee member)
Hinze, Willie L. (committee member)
Jones, Paul B. (committee member)
King, S. Bruce (committee member)
date
2020-01-08T09:35:20Z (accessioned)
2019 (issued)
degree
Chemistry (discipline)
2022-01-07 (liftdate)
embargo
2022-01-07 (terms)
identifier
http://hdl.handle.net/10339/95945 (uri)
language
en (iso)
publisher
Wake Forest University
title
CAPILLARY ELECTROPHORESIS-BASED CHARACTERIZATION AND APPLICATIONS OF CARBON DOTS
type
Dissertation

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