Item Details

title

A TLR and CLR Agonist Combination Induces Anti-Tumor Immunity against Peritoneal Carcinomatosis

author

Dyevoich, Allison

abstract

Peritoneal carcinomatosis (PC) is a condition where primary tumors metastasize into the peritoneal cavity and induce malignant ascites. One strategy currently being explored to treat malignancies involves leukocyte activation through pattern recognition receptors (PRRs), including Toll-Like Receptors (TLRs) and C-type Lectin Receptors (CLRs). Our data shows that mice treated with a TLR and CLR agonist combination are afforded significant protection when challenged with an aggressive ascites-forming mammary tumor cell line (TA3-Ha). However, when mice lack B-1a cells, the protection is lost. Activated, antibody-secreting cells (ASCs) are found in the spleen, peritoneal cavity and visceral adipose tissue (VAT). Consistent with ASC differentiation, the treatment induces a significant increase in IgM and complement (C’) bound to tumor cells, both of which are critical components in the antitumor effect.

subject

Innate Immunity

Natural Antibody

Pattern Recognition Receptors

Type I Interferon

contributor

Haas, Karen M (committee chair)

Alexander-Miller, Martha (committee member)

Debinski, Waldemar (committee member)

Lyles, Douglas (committee member)

date

2020-01-08T09:35:21Z (accessioned)

2024-12-30T09:30:09Z (available)

2019 (issued)

degree

Microbiology & Immunology (discipline)

embargo

2024-12-30 (terms)

identifier

http://hdl.handle.net/10339/95947 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation