Item Details

title

COMPLEX NETWORK ARCHITECTURE, WHITE MATTER MICROSTRUCTURE, AND COGNITIVE DEFICITS IN TRAUMATIC BRAIN INJURY AND POST-TRAUMATIC STRESS DISORDER

author

Singleton, Omar

abstract

The wars in Iraq and Afghanistan from 2001 to 2014, officially designated as Operation Iraqi Freedom (OIF), Operation Enduring Freedom (OEF), and Operation New Dawn (OND), respectively, have resulted in more than 2.5 million Veterans from these conflicts who have now returned to the United States, struggle to reintegrate into society, and suffer from high rates of physical and psychological trauma and injury. The impact of TBI and PTSD are especially devastating and collectively reduce quality of life for OIF/OEF Veterans, with prevalence of TBI and PTSD among these Veterans estimated at 6.7 to 20% and 29.3%, respectively. Comorbidity of TBI and PTSD is common and impacts recovery and outcomes in addition to complicating our understanding of the neurobiology of these conditions. There remains a gap in the characterization of brain structure and function in TBI, especially blast-related TBI, and PTSD. Considering that the burden of TBI and PTSD on Veterans has widespread societal implications, understanding the complex relationship between structural, functional, and cognitive changes induced by these conditions is extremely important. The aims of the present study were to (a) characterize the functional network architecture of the brain in blast TBI and PTSD; (b) investigate the effects of neurotrauma on overall white matter tracts and limbic-related white matter tracts; (c) evaluate the extent to which blast TBI interacts with PTSD to impact brain structure and function; and (d) examine the disparity in neurological effects and outcome based on minority status.

subject

cognition

dti

fmri

network science

neuroimaging

contributor

Godwin, Dwayne (committee chair)

Hamilton, Craig A (committee member)

Rowland, Jared A (committee member)

date

2020-01-08T09:35:21Z (accessioned)

2022-01-07T09:30:12Z (available)

2019 (issued)

degree

Health Disparities in Neuroscience-related Disorders – MS (discipline)

embargo

2022-01-07 (terms)

identifier

http://hdl.handle.net/10339/95948 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis