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Changes in Brain Network Efficiency and Working Memory Performance in Aging

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abstract
Working memory is a complex psychological construct referring to the temporary storage and active processing of information. We used functional connectivity brain network metrics quantifying local and global efficiency of information transfer for predicting individual variability in working memory performance on an n-back task in both young (n = 14) and older (n = 15) adults. Individual differences in both local and global efficiency during the working memory task were significant predictors of working memory performance in addition to age (and an interaction between age and global efficiency). Decreases in local efficiency during the working memory task were associated with better working memory performance in both age cohorts. In contrast, increases in global efficiency were associated with much better working performance for young participants; however, increases in global efficiency were associated with a slight decrease in working memory performance for older participants. Individual differences in local and global efficiency during resting-state sessions were not significant predictors of working memory performance. Significant group whole-brain functional network decreases in local efficiency also were observed during the working memory task compared to rest, whereas no significant differences were observed in network global efficiency. These results are discussed in relation to recently developed models of age-related differences in working memory.
subject
Working memory
Neural networks
Age groups
Elderly
contributor
Stanley, ML (author)
Simpson, SL (author)
Dagenbach, D (author)
Lyday, RG (author)
Burdette, JH (author)
Laurienti, PJ (author)
date
2020-02-03T20:12:53Z (accessioned)
2020-02-03T20:12:53Z (available)
4/13/15 (issued)
identifier
Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ (2015) Changes in Brain Network Efficiency and Working Memory Performance in Aging. PLoS ONE 10(4): e0123950. (citation)
https://doi.org/10.1371/journal.pone.0123950 (doi)
http://hdl.handle.net/10339/95966 (uri)
language
en_US (iso)
publisher
PLOS
source
PLOS ONE
title
Changes in Brain Network Efficiency and Working Memory Performance in Aging
type
Article

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