Home WakeSpace Scholarship › Open Access Fund Publications

Erythrocytic bioactivation of nitrite and its potentiation by far-red light

Open Access Fund Publications

Item Files

Item Details

abstract
Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (RBCs) is the main erythrocytic protein responsible for mediating nitrite-dependent NO signaling. In other work, infrared and far red light have been shown to have therapeutic potential that some attribute to production of NO. Here we explore whether a combination of nitrite and far red light treatment has an additive effect in NO-dependent processes, and whether this effect is mediated by RBCs.
subject
Nitric oxide
Nitrite
Hemoglobin
Photobiomodulation
contributor
Wajih, N. (author)
Basu, S. (author)
Ucer, K. (author)
Rigal, F. (author)
Kim-Shapiro, D. (author)
date
2020-03-09T19:29:31Z (accessioned)
2020-03-09T19:29:31Z (available)
2019-01 (issued)
identifier
Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB. Erythrocytic bioactivation of nitrite and its potentiation by far-red light. Redox Biology. 20: 442-450. (citation)
https://www.sciencedirect.com/science/article/pii/S2213231718309261?via%3Dihub (doi)
http://hdl.handle.net/10339/96055 (uri)
language
en (iso)
publisher
Elsevier
rights
https://creativecommons.org/licenses/by-nc-nd/2.0/ (uri)
source
Redox Biology
title
Erythrocytic bioactivation of nitrite and its potentiation by far-red light
type
Article

Usage Statistics