Item Details

abstract

Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (RBCs) is the main erythrocytic protein responsible for mediating nitrite-dependent NO signaling. In other work, infrared and far red light have been shown to have therapeutic potential that some attribute to production of NO. Here we explore whether a combination of nitrite and far red light treatment has an additive effect in NO-dependent processes, and whether this effect is mediated by RBCs.

subject

Nitric oxide

Nitrite

Hemoglobin

Photobiomodulation

contributor

Wajih, N. (author)

Basu, S. (author)

Ucer, K. (author)

Rigal, F. (author)

Kim-Shapiro, D. (author)

date

2020-03-09T19:29:31Z (accessioned)

2020-03-09T19:29:31Z (available)

2019-01 (issued)

identifier

Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB. Erythrocytic bioactivation of nitrite and its potentiation by far-red light. Redox Biology. 20: 442-450. (citation)

https://www.sciencedirect.com/science/article/pii/S2213231718309261?via%3Dihub (doi)

http://hdl.handle.net/10339/96055 (uri)

language

en (iso)

publisher

Elsevier

rights

https://creativecommons.org/licenses/by-nc-nd/2.0/ (uri)

source

Redox Biology

title

Erythrocytic bioactivation of nitrite and its potentiation by far-red light

type

Article