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Erythrocytic bioactivation of nitrite and its potentiation by far-red light

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title
Erythrocytic bioactivation of nitrite and its potentiation by far-red light
author
Wajih, N.
author
Basu, S.
author
Ucer, K.
author
Rigal, F.
author
Kim-Shapiro, D.
abstract
Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (RBCs) is the main erythrocytic protein responsible for mediating nitrite-dependent NO signaling. In other work, infrared and far red light have been shown to have therapeutic potential that some attribute to production of NO. Here we explore whether a combination of nitrite and far red light treatment has an additive effect in NO-dependent processes, and whether this effect is mediated by RBCs.
subject
Nitric oxide
Nitrite
Hemoglobin
Photobiomodulation
date
2020-03-09T19:29:31Z (accessioned)
2020-03-09T19:29:31Z (available)
2019-01 (issued)
identifier
Wajih N, Basu S, Ucer KB, Rigal F, Shakya A, Rahbar E, Vachharajani V, Guthold M, Gladwin MT, Smith LM, Kim-Shapiro DB. Erythrocytic bioactivation of nitrite and its potentiation by far-red light. Redox Biology. 20: 442-450. (citation)
http://hdl.handle.net/10339/96055 (uri)
identifier
https://www.sciencedirect.com/science/article/pii/S2213231718309261?via%3Dihub (doi)
language
en (iso)
publisher
Elsevier
rights
https://creativecommons.org/licenses/by-nc-nd/2.0/ (uri)
source
Redox Biology
type
Article

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