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OSTEOARTHRITIS PROMOTES PROSTATE CANCER PROGRESSION

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abstract
Introduction: Cancer is the second greatest cause of death in the United States. Furthermore, an estimated 31,000 deaths occur annually affecting the quality of life of those who survive it. Therefore, great interest has been directed at identifying treatable risk factors that could decrease the incidence or the progression of this debilitating disease. The purpose of this dissertation was to evaluate whether osteoarthritis, an enormously prevalent disease, affected the prostate cancer patients. The molecular basis of this association lies in research that uncovered that prostate cancer tumors expressing cartilage oligomeric matrix protein (COMP) have worse outcomes compared to tumors not overexpressing this protein. COMP is found in high concentrations in the serum of patients with osteoarthritis and as such may be the link between these two conditions.
subject
arthritis
arthroplasty
biology
correlation
prostate cancer
contributor
Rosas, Samuel (author)
Willey, Jeffrey S (committee chair)
Willey, Jeffrey S (committee member)
Kerr, Bethany A (committee member)
Emory, Cynthia L (committee member)
Smith, Thomas L (committee member)
Tallant, E. Ann (committee member)
Yammani, Raghunatha (committee member)
date
2020-05-29T08:35:32Z (accessioned)
2020-05-29T08:35:32Z (available)
2020 (issued)
degree
Molecular Medicine and Translational Science (discipline)
identifier
http://hdl.handle.net/10339/96788 (uri)
language
en (iso)
publisher
Wake Forest University
title
OSTEOARTHRITIS PROMOTES PROSTATE CANCER PROGRESSION
type
Dissertation

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