RGS2 PROTEINS REGULATE DOPAMINE SIGNALING AND COCAINE SELF-ADMINISTRATION VIA DOPAMINE D2 AUTORECEPTORS
Electronic Theses and Dissertations
Item Files
Item Details
- abstract
- Dopamine (DA) is critically involved in the etiology of drug addiction. A key modulator of DAergic transmission is the dopamine D2 autoreceptor (D2AR), which couples to Gαi/o proteins to inhibit adenylyl cyclase activity. The D2ARs located on midbrain DAergic neurons modulate DA neuron firing as well as DA synthesis, release, and reuptake through a negative feedback mechanism. Extensive preclinical evidence has consistently shown that chronic exposure to psychostimulants reduces D2AR function, which is associated with vulnerability to relapse. Newly emerged preclinical and clinical data indicate that low levels of D2AR expression and function are associated with enhanced drug reward. To date, there is a significant knowledge gap in understanding the cellular regulation of D2AR activity by drugs of abuse.
- subject
- Cocaine
- D2 Dopamine Receptor (D2R)
- Dopamine
- Drug Addiction
- G protein Coupled Receptor (GPCR)
- Regulator of G protein Signaling (RGS) Proteins
- contributor
- Chen, Rong (committee chair)
- Martin, Thomas J (committee member)
- McCool, Brian A (committee member)
- Howlett, Allyn C (committee member)
- Jones, Sara R (committee member)
- Ferris, Mark J (committee member)
- date
- 2020-05-29T08:35:36Z (accessioned)
- 2020 (issued)
- degree
- Physiology and Pharmacology (discipline)
- 2022-05-28 (liftdate)
- embargo
- 2022-05-28 (terms)
- identifier
- http://hdl.handle.net/10339/96789 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- RGS2 PROTEINS REGULATE DOPAMINE SIGNALING AND COCAINE SELF-ADMINISTRATION VIA DOPAMINE D2 AUTORECEPTORS
- type
- Dissertation