Item Details

abstract

Dopamine (DA) is critically involved in the etiology of drug addiction. A key modulator of DAergic transmission is the dopamine D2 autoreceptor (D2AR), which couples to Gαi/o proteins to inhibit adenylyl cyclase activity. The D2ARs located on midbrain DAergic neurons modulate DA neuron firing as well as DA synthesis, release, and reuptake through a negative feedback mechanism. Extensive preclinical evidence has consistently shown that chronic exposure to psychostimulants reduces D2AR function, which is associated with vulnerability to relapse. Newly emerged preclinical and clinical data indicate that low levels of D2AR expression and function are associated with enhanced drug reward. To date, there is a significant knowledge gap in understanding the cellular regulation of D2AR activity by drugs of abuse.

subject

Cocaine

D2 Dopamine Receptor (D2R)

Dopamine

Drug Addiction

G protein Coupled Receptor (GPCR)

Regulator of G protein Signaling (RGS) Proteins

contributor

Luessen, Deborah Joyce (author)

Chen, Rong (committee chair)

Martin, Thomas J (committee member)

McCool, Brian A (committee member)

Howlett, Allyn C (committee member)

Jones, Sara R (committee member)

Ferris, Mark J (committee member)

date

2020-05-29T08:35:36Z (accessioned)

2020 (issued)

degree

Physiology and Pharmacology (discipline)

2022-05-28 (liftdate)

embargo

2022-05-28 (terms)

identifier

http://hdl.handle.net/10339/96789 (uri)

language

en (iso)

publisher

Wake Forest University

title

RGS2 PROTEINS REGULATE DOPAMINE SIGNALING AND COCAINE SELF-ADMINISTRATION VIA DOPAMINE D2 AUTORECEPTORS

type

Dissertation