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SYNBIOTIC YOGURT PREVENTS DIABETES PROGRESSION THROUGH IMPROVEMENTS IN THE MICROBIOME-INTESTINE-PANCREAS AXIS

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abstract
Type-2 diabetes mellitus (T2D) is a chronic disease characterized by increased blood glucose (hyperglycemia) and insulin resistance in peripheral metabolic organs, which hampers glucose clearance and leads to pancreatic beta cell dysfunction and reduced insulin secretion. Research has revealed the gut microbiome as a superlative regulator of metabolic health and the therapeutic effects of microbiome modulators, such as probiotics, prebiotics, and synbiotics, are emerging. Therefore, innovative and effective probiotics and/or prebiotics are in high demand to ameliorate diabetes. This study investigated the protective effects of a novel synbiotic yogurt (containing five human-origin Lactobacillus probiotics and a prebiotic isolated from sago) on the progression of T2D in a high-fat diet/streptozotocin-induced diabetic mouse model and compared its effects to those of a commercially-available yogurt. Synbiotic yogurt-fed mice exhibited improved fasting blood glucose and meal tolerance via protection of beta cells and intestinal physiology and favorable modulation of the gut microbiome. Surprisingly, mice fed the commercial yogurt demonstrated gut microbiome dysbiosis and damage to beta cells, which aggravated T2D progression. This study suggests that our novel synbiotic yogurt protects against diabetes, but raises concerns regarding the use of commercial yogurts in the progression of diabetes. Further studies are necessary to address these concerns.
subject
Gut microbiome
Metabolism
Prebiotics
Probiotics
Synbiotic yogurt
Type-2 diabetes mellitus
contributor
Miller, Brandi Ciara (author)
Yadav, Hariom (committee chair)
Solberg-Woods, Leah (committee member)
Yammani, Raghunatha (committee member)
date
2020-05-29T08:35:54Z (accessioned)
2021-05-28T08:30:12Z (available)
2020 (issued)
degree
Biomedical Science – MS (discipline)
embargo
2021-05-28 (terms)
identifier
http://hdl.handle.net/10339/96814 (uri)
language
en (iso)
publisher
Wake Forest University
title
SYNBIOTIC YOGURT PREVENTS DIABETES PROGRESSION THROUGH IMPROVEMENTS IN THE MICROBIOME-INTESTINE-PANCREAS AXIS
type
Thesis

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