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Millisecond Interval Time Perception in Patients with Parkinson’s Disease On and Off of Dopamine Replacement Therapies

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abstract
Human time perception is mediated by dopamine in the striatum, which is one of the same regions impacted by Parkinson’s disease (PD). PD patients experience motor and cognitive changes due to the loss of striatal dopamine neurons. Dopamine replacement therapy is the first line of treatment to replace the dopamine lost in the striatum and to combat the motor symptoms of PD. While much is known about how dopamine replacement helps alleviate the motor symptoms, less is known about its impact on cognitive changes associated with PD. This study investigates the intermediating effects of dopamine replacement therapy on time perception in PD patients, and it serves as a pilot project for near-term work aimed at directly measuring dopamine’s role in human time perception. Through the use of a temporal bisection task measuring millisecond time intervals, PD subjects showed deficits in temporal accuracy when compared to healthy controls. There were no differences in temporal precision found in PD patients after withholding their normally prescribed dopamine replacement therapy. Additionally, medication dosages and disease duration were not significant predictors of time perception abilities. This is important to establish the effects of dopamine on the subjective experience of time across disease state and treatment types.
subject
dopamine
dopamine replacement therapy
Parkinson's disease
temporal bisection task
time perception
contributor
DiMarco, Emily (author)
Kishida, Kenneth T (committee chair)
Haq, Ihtsham (committee member)
Terhune, Devin (committee member)
date
2020-05-29T08:36:00Z (accessioned)
2022-05-28T08:30:13Z (available)
2020 (issued)
degree
Neuroscience (discipline)
embargo
2022-05-28 (terms)
identifier
http://hdl.handle.net/10339/96822 (uri)
language
en (iso)
publisher
Wake Forest University
title
Millisecond Interval Time Perception in Patients with Parkinson’s Disease On and Off of Dopamine Replacement Therapies
type
Thesis

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