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CHARACTERIZING ALZHEIMER’S DISEASE PATHOLOGY AND MOLECULAR SIGNALING DYSREGULATION IN AGED CYNOMOLGUS MACAQUES WITH NORMAL AND HIGH BLOOD GLUCOSE

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abstract
Alzheimer’s disease (AD) is one of the most prevalent health concerns in our society today. There are 5.8 million people currently diagnosed with AD in the United States alone, and this number is only expected to increase as more of the population gets older. The underlying mechanisms of AD are still unknown and this has largely prevented the development of efficacious therapies or treatments. There are numerous factors that contribute to a person’s risk of developing AD. In terms of modifiable risk factors, many are metabolic in nature and contribute to risk of cardiovascular disease as well. These include type 2 diabetes mellitus (T2DM), obesity, insulin resistance, and elevated glucose levels. It has been determined that those with T2DM have a 73% higher relative risk for developing any type of dementia than those without T2DM, and a 56% increased risk for developing Alzheimer’s disease specifically. Several studies have associated insulin resistance and T2DM with cognitive decline. The increased risk and comorbidity of these metabolic disorders with AD have led to questions about possible common etiologies or underlying mechanisms of these diseases. Indeed, there are pathophysiological elements common among metabolic disorders and AD that are detrimental to synaptic plasticity and cognitive function. Non-human primate (NHP) models of T2DM and AD may prove to be incredibly useful in understanding the molecular links between T2DM and AD since both diseases are naturally occurring in many species of NHPs.
subject
Alzheimer's
Diabetes
Insulin Resistance
Molecular signaling
Non-human primates
Pathology
contributor
Jester, Hannah Marie (author)
Ma, Tao (committee chair)
Macauley-Rambach, Shannon L (committee member)
Ko, Mei-Chuan (committee member)
date
2020-05-29T08:36:04Z (accessioned)
2020-05-29T08:36:04Z (available)
2020 (issued)
degree
Neuroscience – MS (discipline)
identifier
http://hdl.handle.net/10339/96830 (uri)
language
en (iso)
publisher
Wake Forest University
title
CHARACTERIZING ALZHEIMER’S DISEASE PATHOLOGY AND MOLECULAR SIGNALING DYSREGULATION IN AGED CYNOMOLGUS MACAQUES WITH NORMAL AND HIGH BLOOD GLUCOSE
type
Thesis

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