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Effects of Chronic Binge-like Ethanol Drinking on Early Cocaine Sensitivity in Rhesus Monkeys

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abstract
Aim: Most cocaine users also abuse alcohol, but little is known about the interaction between the two. These studies in rhesus monkeys compared the acquisition of cocaine self-administration in monkeys with or without a history of chronic, binge-like alcohol drinking. Raclopride PET imaging and quinpirole-induced yawning were conducted prior to drug exposure to look at the role of dopamine D2-like and D3 receptor availability, respectively, on initial acquisition.
subject
Alcohol
Co-abuse
Cocaine
Dopamine
Self-administration
contributor
Tryhus, Aaron (author)
Czoty, Paul W (committee chair)
Weiner, Jeffrey L (committee member)
Nader, Michael A (committee member)
date
2020-08-28T08:35:29Z (accessioned)
2020-08-28T08:35:29Z (available)
2020 (issued)
degree
Biomedical Science – MS (discipline)
identifier
http://hdl.handle.net/10339/96955 (uri)
language
en (iso)
publisher
Wake Forest University
title
Effects of Chronic Binge-like Ethanol Drinking on Early Cocaine Sensitivity in Rhesus Monkeys
type
Thesis

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