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Pre-clinical Models for Photothermal Nanoparticle Treatment of Colorectal Cancer

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abstract
Peritoneal carcinomatosis of colorectal cancer (pcCRC) is a disease with poor survival outcome and limited treatment options. Standard-of-care treatment for pcCRC involves cytoreduction with systemic chemotherapy, though a five-year survival of only 36.7% is expected with this intervention. The failure of a standardized treatment to address pcCRC is largely attributed to the retention of micrometastases within the peritoneal cavity, where small size allows the disease to remain undetected during cytoreduction and therapeutic resistance limits chemotherapeutic efficacy.
subject
Cancer
Colorectal
Hyperthermia
Nanoparticle
Organoid
Photothermal
contributor
McCarthy, Bryce David (author)
Levi-Polyachenko, Nicole (committee chair)
Hall, Adam (committee member)
Singh, Ravi (committee member)
Votanopoulos, Konstantinos (committee member)
date
2020-08-28T08:35:32Z (accessioned)
2020 (issued)
degree
Biomedical Engineering (discipline)
2022-08-27 (liftdate)
embargo
2022-08-27 (terms)
identifier
http://hdl.handle.net/10339/96959 (uri)
language
en (iso)
publisher
Wake Forest University
title
Pre-clinical Models for Photothermal Nanoparticle Treatment of Colorectal Cancer
type
Dissertation

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