Home WakeSpace Scholarship › Electronic Theses and Dissertations

Architectural Properties of the Tumor Microenvironment Control Cancer Progression

Electronic Theses and Dissertations

Item Files

Item Details

abstract
Tumors consist of cancer cells surrounded by a complex organization of stromal cells and a lattice of extracellular matrices (ECM), referred to as the tumor microenvironment (TME), that has a significant role in regulating tumor growth, cancer malignancy and chemotherapy treatment response. Cancerous tissue often grows undetected in a non-invasive state for years without detection. With time, cancer can shift from being benign to malignant due to many influences, including a transformation in the TME. Malignant cells will then metastasize to localized regions of the body where the new environment will go through changes to allow colonization, establishing a new TME.
subject
3D Cell Culture
Bioengineering
Cancer
Tumor Microenvironment
Tumor Organoids
contributor
Dominijanni, Anthony (author)
Soker, Shay S (committee chair)
Gmeiner, William H (committee member)
Votanopoulos, Konstantinos (committee member)
Xing, Fei (committee member)
Criswell, Tracy L (committee member)
date
2021-06-03T08:35:48Z (accessioned)
2021-12-02T09:30:13Z (available)
2021 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2021-12-02 (terms)
identifier
http://hdl.handle.net/10339/98777 (uri)
language
en (iso)
publisher
Wake Forest University
title
Architectural Properties of the Tumor Microenvironment Control Cancer Progression
type
Dissertation

Usage Statistics