Item Details

title

Architectural Properties of the Tumor Microenvironment Control Cancer Progression

author

Dominijanni, Anthony

abstract

Tumors consist of cancer cells surrounded by a complex organization of stromal cells and a lattice of extracellular matrices (ECM), referred to as the tumor microenvironment (TME), that has a significant role in regulating tumor growth, cancer malignancy and chemotherapy treatment response. Cancerous tissue often grows undetected in a non-invasive state for years without detection. With time, cancer can shift from being benign to malignant due to many influences, including a transformation in the TME. Malignant cells will then metastasize to localized regions of the body where the new environment will go through changes to allow colonization, establishing a new TME.

subject

3D Cell Culture

Bioengineering

Cancer

Tumor Microenvironment

Tumor Organoids

contributor

Soker, Shay S (committee chair)

Gmeiner, William H (committee member)

Votanopoulos, Konstantinos (committee member)

Xing, Fei (committee member)

Criswell, Tracy L (committee member)

date

2021-06-03T08:35:48Z (accessioned)

2021-12-02T09:30:13Z (available)

2021 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2021-12-02 (terms)

identifier

http://hdl.handle.net/10339/98777 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation