Item Details

title

IDENTIFICATION OF SENSITIVITY TO SILVER NANOPARTICLE INDUCED LIPID AND PROTEIN OXIDATION AS AN EXPLOITABLE VULNERABILITY OF EGFR-TKI RESISTANT CANCERS

author

Rohde, Monica

abstract

Lung cancer is the leading cause of cancer related deaths worldwide and is the second most commonly diagnosed cancer among men and women. Due to advances in genetic screening, targeted therapies have been developed to treat lung cancers that exhibit aberrant expression of epidermal growth factor receptor (EGFR). However, the success of EGFR-tyrosine kinase inhibitors (TKIs) has been hampered due to the development of resistance over the course of treatment. Therefore, the discovery of new drugs to treat those that do not initially respond, or stop responding over time, is increasingly important.

subject

drug resistance

lung cancer

nanomaterials

oxidative stress

silver

contributor

Singh, Ravi N (committee chair)

Murphy, Sean V (committee member)

Kridel, Steven J (committee member)

Furdui, Cristina M (committee member)

Miller, Lance D (committee member)

date

2021-06-03T08:35:49Z (accessioned)

2022-06-02T08:30:12Z (available)

2021 (issued)

degree

Cancer Biology (discipline)

embargo

2022-06-02 (terms)

identifier

http://hdl.handle.net/10339/98778 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation