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IDENTIFICATION OF SENSITIVITY TO SILVER NANOPARTICLE INDUCED LIPID AND PROTEIN OXIDATION AS AN EXPLOITABLE VULNERABILITY OF EGFR-TKI RESISTANT CANCERS

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abstract
Lung cancer is the leading cause of cancer related deaths worldwide and is the second most commonly diagnosed cancer among men and women. Due to advances in genetic screening, targeted therapies have been developed to treat lung cancers that exhibit aberrant expression of epidermal growth factor receptor (EGFR). However, the success of EGFR-tyrosine kinase inhibitors (TKIs) has been hampered due to the development of resistance over the course of treatment. Therefore, the discovery of new drugs to treat those that do not initially respond, or stop responding over time, is increasingly important.
subject
drug resistance
lung cancer
nanomaterials
oxidative stress
silver
contributor
Rohde, Monica (author)
Singh, Ravi N (committee chair)
Murphy, Sean V (committee member)
Kridel, Steven J (committee member)
Furdui, Cristina M (committee member)
Miller, Lance D (committee member)
date
2021-06-03T08:35:49Z (accessioned)
2021 (issued)
degree
Cancer Biology (discipline)
2022-06-02 (liftdate)
embargo
2022-06-02 (terms)
identifier
http://hdl.handle.net/10339/98778 (uri)
language
en (iso)
publisher
Wake Forest University
title
IDENTIFICATION OF SENSITIVITY TO SILVER NANOPARTICLE INDUCED LIPID AND PROTEIN OXIDATION AS AN EXPLOITABLE VULNERABILITY OF EGFR-TKI RESISTANT CANCERS
type
Dissertation

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