Item Details

title

PREDICTORS OF CLINICALLY MEANINGFUL GAIT SPEED RESPONSE TO CALORIC RESTRICTION AMONG OLDER ADULTS PARTICIPATING IN WEIGHT LOSS INTERVENTIONS

author

Tse, Ka Ki

abstract

The purpose of this study was to examine whether select baseline characteristics influence the likelihood of an older adult experiencing a clinically meaningful gait speed response (±0.05 m/s) to caloric restriction. Individual level data from 1188 older adults participating in eight, five/six-month, dietary-based weight loss interventions were pooled, with treatment arms collapsed into caloric restriction (CR; n=667) or no caloric restriction (NoCR; n=521) categories. Poisson risk ratios (95% CI) were used to examine whether CR assignment interacted with select baseline characteristic subgroups (age, sex, race, BMI, comorbidity status, baseline gait speed, or inflammatory burden) to influence achievement of ±0.05 m/s fast gait speed change. Main effects were also examined. The study sample (69.5% female, 80.1% white) was 67.6±5.3 years old with a BMI of 33.8±4.4 kg/m2. Interaction effects were non-significant across all subgroups. However, those with low baseline gait speed were more likely to experience a clinically meaningful gait speed improvement; and, females and those with hypertension or CVD were more likely to experience a gait speed decrement, regardless of CR assignment (all p≤0.04). Compared with NoCR, CR does not result in a clinically meaningful change in gait speed among older adults. This finding is robust across several baseline subgroupings.

subject

Clinical trial

Gait speed

Obesity

Older adults

Physical function

Weight loss

contributor

Beavers, Kristen M (committee chair)

Messier, Stephen P (committee member)

Beavers, Daniel P (committee member)

date

2021-06-03T08:35:53Z (accessioned)

2022-06-02T08:30:11Z (available)

2021 (issued)

degree

Health and Exercise Science (discipline)

embargo

2022-06-02 (terms)

identifier

http://hdl.handle.net/10339/98783 (uri)

language

en (iso)

publisher

Wake Forest University

type

Thesis