Home WakeSpace Scholarship › Electronic Theses and Dissertations

Community Organization of Resting-State Functional Connectivity in the Depressed Brain

Electronic Theses and Dissertations

Item Files

Item Details

abstract
Depression is a serious, highly heterogenous psychiatric condition with myriad consequences for individuals and society at large. Research into its neural underpinnings is critical in order to better understand the condition and thus improve treatment and prevention. Using the methodology of network science applied to fMRI data, patterns of altered functional connectivity in resting-state brain networks have been observed in depressed individuals. The present study sought to further investigate the nature of these differences by examining community structure and inter-community connectivity in the brains of depressed individuals and healthy controls. Using resting-state fMRI and behavioral data from Depression and Anxiety scales from the Human Connectome Project (HCP), the organization of functional connectivity in the brain was examined in depressed and non-depressed groups. This analysis revealed that when depressed individuals were categorized into subgroups with and without comorbid Anxiety, the solely depressed subgroup showed significantly lower consistency of the default mode network (DMN) compared to the subgroup with comorbid Anxiety. This finding contributes an interesting piece of evidence to the understanding that subtypes of Depression show differing patterns of alteration of functional connectivity, and it emphasizes the importance of considering these distinctions in treatment for Depression, especially those targeting the DMN.
subject
anxiety
default mode network
depression
modularity
network neuroscience
contributor
Frye, Natalie Grace (author)
Dagenbach, Dale (committee chair)
Blumenthal, Terry D (committee member)
Waugh, Christian (committee member)
Laurienti, Paul J (committee member)
date
2021-06-03T08:35:58Z (accessioned)
2021 (issued)
degree
Psychology (discipline)
2023-06-02 (liftdate)
embargo
2023-06-02 (terms)
identifier
http://hdl.handle.net/10339/98791 (uri)
language
en (iso)
publisher
Wake Forest University
title
Community Organization of Resting-State Functional Connectivity in the Depressed Brain
type
Thesis

Usage Statistics