Item Details

abstract

Breast cancer is the most prevalent cancer in the United States and the second leading cause of cancer death in American women. Human epidermal growth factor receptor 2 (HER2) positive breast cancer, characterized by overexpression of the HER2 protein, is an aggressive type of breast cancer comprising ~20% of diagnosed cases. Although targeted HER2 drugs such as trastuzumab (TRZ) reduce mortality by about one-third, many patients still experience primary or acquired resistance, highlighting the need for additional therapies. TRZ is also cardiotoxic, in part by increasing reactive oxygen species, resulting in left ventricular (LV) systolic dysfunction in up to 25% of patients. Grape seed/skin extracts are popular dietary supplements due to their potent antioxidant and anti-inflammatory properties. However, extracts from muscadine grapes are not extensively studied and data regarding their therapeutic effects on cancer and TRZ-induced cardiotoxicity are limited.

subject

Breast Cancer

Cardiotoxicity

HER2

Muscadine Grape

Polyphenol

Trastuzumab Resistance

contributor

Mackert, Jessica (author)

Gallagher, Patricia (committee chair)

Gmeiner, William (committee member)

Cook, Katherine (committee member)

Deep, Gagan (committee member)

date

2021-06-03T08:36:04Z (accessioned)

2022-06-02T08:30:12Z (available)

2021 (issued)

degree

Physiology and Pharmacology (discipline)

embargo

2022-06-02 (terms)

identifier

http://hdl.handle.net/10339/98794 (uri)

language

en (iso)

publisher

Wake Forest University

title

A MUSCADINE GRAPE EXTRACT INHIBITS HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER AND TRASTUZUMAB-INDUCED CARDIOTOXICITY

type

Dissertation