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A MUSCADINE GRAPE EXTRACT INHIBITS HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER AND TRASTUZUMAB-INDUCED CARDIOTOXICITY

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abstract
Breast cancer is the most prevalent cancer in the United States and the second leading cause of cancer death in American women. Human epidermal growth factor receptor 2 (HER2) positive breast cancer, characterized by overexpression of the HER2 protein, is an aggressive type of breast cancer comprising ~20% of diagnosed cases. Although targeted HER2 drugs such as trastuzumab (TRZ) reduce mortality by about one-third, many patients still experience primary or acquired resistance, highlighting the need for additional therapies. TRZ is also cardiotoxic, in part by increasing reactive oxygen species, resulting in left ventricular (LV) systolic dysfunction in up to 25% of patients. Grape seed/skin extracts are popular dietary supplements due to their potent antioxidant and anti-inflammatory properties. However, extracts from muscadine grapes are not extensively studied and data regarding their therapeutic effects on cancer and TRZ-induced cardiotoxicity are limited.
subject
Breast Cancer
Cardiotoxicity
HER2
Muscadine Grape
Polyphenol
Trastuzumab Resistance
contributor
Mackert, Jessica (author)
Gallagher, Patricia (committee chair)
Gmeiner, William (committee member)
Cook, Katherine (committee member)
Deep, Gagan (committee member)
date
2021-06-03T08:36:04Z (accessioned)
2021 (issued)
degree
Physiology and Pharmacology (discipline)
2022-06-02 (liftdate)
embargo
2022-06-02 (terms)
identifier
http://hdl.handle.net/10339/98794 (uri)
language
en (iso)
publisher
Wake Forest University
title
A MUSCADINE GRAPE EXTRACT INHIBITS HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER AND TRASTUZUMAB-INDUCED CARDIOTOXICITY
type
Dissertation

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