Item Details

abstract

Introduction: In the United States, an estimated 5.2 million musculoskeletal surgeries are performed every year, and nearly half of these utilize bone grafts. The economic and clinical implications of bone grafting are enormous, and as a result, tissue-engineered bone graft substitutes have garnered considerable attention in recent years. We have developed a scaffold derived from porcine cancellous bone using a decellularization protocol previously developed in our laboratory. The goal of this work is to examine the healing potential of this porcine xenograft. We plan on carrying this out by assessing the osteoinductive capabilities of the xenograft. We hypothesize that the xenograft environment will induce enhanced osteogenic differentiation in vitro and in vivo. Furthermore we hypothesize that this decellularized porcine scaffold will be biocompatabile and have at least equivalent osseointegration when compared to demineralized bone matrix (DBM). Research Problem: Does a porcine bone xenograft maintain its native osteoinductivity, osseointegrate, and become biocompatible after undergoing a patented decellularization and oxidation protocol?

subject

contributor

Jinnah, Alexander H (author)

Willey, Jeffrey S (committee chair)

Emory, Cynthia L (committee member)

Smitgh, Thomas L (committee member)

Kerr, Bethany A (committee member)

date

2021-06-03T08:36:05Z (accessioned)

2021-12-02T09:30:13Z (available)

2021 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2021-12-02 (terms)

identifier

http://hdl.handle.net/10339/98797 (uri)

language

en (iso)

publisher

Wake Forest University

title

DECELLULARIZED PORCINE XENOGRAFT IS OSTEOINDUCTIVE AND HAS IMPROVED OSSEOINTEGRATION COMPARED TO DEMINERALIZED BONE MATRIX

type

Dissertation