Item Details

title

DUAL-TARGETING THE DYNORPHIN/KAPPA OPIOID RECEPTOR AND DOPAMINE SYSTEMS FOR TREATMENT OF COCAINE USE DISORDER

author

Estave, Paige

abstract

Decades of research have focused on discovering an effective pharmacotherapy for cocaine use disorder, and despite hundreds of clinical trials testing a wide range of cellular targets, there is still no FDA approved treatment for cocaine addiction. The work contained in this dissertation focuses on the dysregulation of the dopamine and dynorphin/kappa opioid receptor systems that occurs after repeated, high-dose cocaine exposure. These system changes result in a reward deficit, stress surfeit syndrome seen during withdrawal, which leads to greater drug intake and increases the propensity to relapse. The aim of this research was assessing the functional state of the kappa opioid receptor system after cocaine self-administration and the benefits of targeting this system—and its interactions with the dopamine system—to decrease cocaine self-administration and reverse neurobiological alterations resulting from cocaine exposure.

subject

Cocaine

Dopamine

Dynorphin

Kappa

Kappa Opioid Receptor

contributor

Jones, Sara R (committee chair)

Nader, Michael A (committee member)

Ferris, Mark J (committee member)

Raab-Graham, Kimberly F (committee member)

date

2021-06-03T08:36:17Z (accessioned)

2022-06-02T08:30:14Z (available)

2021 (issued)

degree

Neuroscience (discipline)

embargo

2022-06-02 (terms)

identifier

http://hdl.handle.net/10339/98829 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation