Item Details

abstract

Burn injuries are a major clinical burden in the United States, both among military and civilian populations. About 500,000 burn patients are treated annually, and globally there are an estimated 11 million burn injuries per year. Thermal injuries are estimated to constitute 5-20% of military casualties and carry an overall mortality rate of 4.9%. The cost to treat these wounds approaches $2 billion per year in the US alone. The standard of care for burn injuries includes autologous skin grafting, which allows wound coverage and closure and helps reduce scarring from full-thickness wounds [4-6]. However, autologous grafting requires sufficient amounts of skin harvest sites, and in burn patients, the availability of donor sites can be limited by extensive skin loss. Furthermore, the donor site often develops fibrotic scarring and contracture, resulting in significant morbidities.

subject

Bioprinting

Cell and Tissue Culture

Regenerative Medicine

Skin Tissue Engineering

Transplantation

Wound Healing

contributor

Jorgensen, Adam M (author)

Atala, Anthony (committee chair)

Molnar, Joseph (committee member)

Lee, Sang Jin (committee member)

Murphy, Sean V (committee member)

date

2021-06-03T08:36:17Z (accessioned)

2021 (issued)

degree

Molecular Medicine and Translational Science (discipline)

2026-05-17 (liftdate)

embargo

2026-05-17 (terms)

identifier

http://hdl.handle.net/10339/98830 (uri)

language

en (iso)

publisher

Wake Forest University

title

BIOPRINTED SKIN FOR TREATMENT OF FULL-THICKNESS SKIN INJURIES

type

Dissertation