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BIOPRINTED SKIN FOR TREATMENT OF FULL-THICKNESS SKIN INJURIES

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title
BIOPRINTED SKIN FOR TREATMENT OF FULL-THICKNESS SKIN INJURIES
author
Jorgensen, Adam M
abstract
Burn injuries are a major clinical burden in the United States, both among military and civilian populations. About 500,000 burn patients are treated annually, and globally there are an estimated 11 million burn injuries per year. Thermal injuries are estimated to constitute 5-20% of military casualties and carry an overall mortality rate of 4.9%. The cost to treat these wounds approaches $2 billion per year in the US alone. The standard of care for burn injuries includes autologous skin grafting, which allows wound coverage and closure and helps reduce scarring from full-thickness wounds [4-6]. However, autologous grafting requires sufficient amounts of skin harvest sites, and in burn patients, the availability of donor sites can be limited by extensive skin loss. Furthermore, the donor site often develops fibrotic scarring and contracture, resulting in significant morbidities.
subject
Bioprinting
Cell and Tissue Culture
Regenerative Medicine
Skin Tissue Engineering
Transplantation
Wound Healing
contributor
Atala, Anthony (committee chair)
Molnar, Joseph (committee member)
Lee, Sang Jin (committee member)
Murphy, Sean V (committee member)
date
2021-06-03T08:36:17Z (accessioned)
2021 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2026-05-17 (terms)
2026-05-17 (liftdate)
identifier
http://hdl.handle.net/10339/98830 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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