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Development of an Automated Pipeline to Analyze Hippocampal Morphometry in Response to Neurodegenerative Diseases

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abstract
Alzheimer’s Disease, a neurodegenerative disorder that results in dementia and profound memory loss over time, is the 6th leading cause of death in the United States. Damage to and deterioration of the hippocampus—a structure within the brain that is responsible for the encoding and retrieval of episodic memories—is one of the defining features of the onset and development of Alzheimer’s Disease. Deterioration of hippocampal function is often indicative of synaptic dysfunction or neuron loss, the latter of which can be quantified through morphometric analysis of the hippocampus.
subject
hippocampus
morphometrics
morphometry
MRI
pipeline
shape analysis
contributor
Madi, Kedar Vijay (author)
Whitlow, Christopher T. (committee chair)
Kim, Jeongchul (committee member)
Hampson, Robert E. (committee member)
date
2021-06-03T08:36:18Z (accessioned)
2021 (issued)
degree
Biomedical Engineering (discipline)
2026-05-17 (liftdate)
embargo
2026-05-17 (terms)
identifier
http://hdl.handle.net/10339/98835 (uri)
language
en (iso)
publisher
Wake Forest University
title
Development of an Automated Pipeline to Analyze Hippocampal Morphometry in Response to Neurodegenerative Diseases
type
Thesis

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