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IMAGE BASED DOSIMETRY POST TRANSARTERIAL RADIOEMBOLIZATION

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abstract
Transarterial radioembolization (TARE) is an effective form of treatment for unresectable liver malignancies via strategic injection of radioactive Yttrium-90 (90Y) microspheres to the tumor site. A major hindrance to TARE’s effectiveness is the simplicity of current radiation dosimetry models for the treatment. They lack patient specificity, are minimally image based and potentially underestimate the strength of 90Y required to deliver a tumoricidal radiation dose. This likely limits the treatment from obtaining its full clinical impact 32. However, utilizing positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging, it is possible to gain insight into the dose distribution of treatment through a quick, noninvasive emission imaging method 54. In order to have reliable post-TARE dosimetry, PET and SPECT imaging protocols need to first be optimized specifically to capture 90Y distribution. We hypothesize that post-TARE image based dosimetry will be highly dependent on imaging modality parameters; but once optimized, both SPECT and PET based dose distributions will give comparable results.
subject
image based dosimetry
PET/CT
radiation oncology
SPECT/CT
transarterial radioembolization
Yttrium-90
contributor
Thompson, Briana C (author)
Dezarn, William A (committee chair)
Levi-Polyachenko, Nicole (committee member)
Kouri, Brian (committee member)
McKee, Mahta (committee member)
Gmeiner, William (committee member)
date
2021-06-03T08:36:20Z (accessioned)
2021 (issued)
degree
Molecular Medicine and Translational Science (discipline)
2021-12-02 (liftdate)
embargo
2021-12-02 (terms)
identifier
http://hdl.handle.net/10339/98841 (uri)
language
en (iso)
publisher
Wake Forest University
title
IMAGE BASED DOSIMETRY POST TRANSARTERIAL RADIOEMBOLIZATION
type
Dissertation

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