Item Details

title

IMAGE BASED DOSIMETRY POST TRANSARTERIAL RADIOEMBOLIZATION

author

Thompson, Briana C

abstract

Transarterial radioembolization (TARE) is an effective form of treatment for unresectable liver malignancies via strategic injection of radioactive Yttrium-90 (90Y) microspheres to the tumor site. A major hindrance to TARE’s effectiveness is the simplicity of current radiation dosimetry models for the treatment. They lack patient specificity, are minimally image based and potentially underestimate the strength of 90Y required to deliver a tumoricidal radiation dose. This likely limits the treatment from obtaining its full clinical impact 32. However, utilizing positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging, it is possible to gain insight into the dose distribution of treatment through a quick, noninvasive emission imaging method 54. In order to have reliable post-TARE dosimetry, PET and SPECT imaging protocols need to first be optimized specifically to capture 90Y distribution. We hypothesize that post-TARE image based dosimetry will be highly dependent on imaging modality parameters; but once optimized, both SPECT and PET based dose distributions will give comparable results.

subject

image based dosimetry

PET/CT

radiation oncology

SPECT/CT

transarterial radioembolization

Yttrium-90

contributor

Dezarn, William A (committee chair)

Levi-Polyachenko, Nicole (committee member)

Kouri, Brian (committee member)

McKee, Mahta (committee member)

Gmeiner, William (committee member)

date

2021-06-03T08:36:20Z (accessioned)

2021-12-02T09:30:13Z (available)

2021 (issued)

degree

Molecular Medicine and Translational Science (discipline)

embargo

2021-12-02 (terms)

identifier

http://hdl.handle.net/10339/98841 (uri)

language

en (iso)

publisher

Wake Forest University

type

Dissertation