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LONG-TERM EFFECT OF MUSCADINE GRAPE EXTRACT ON CARDIOVASCULAR FUNCTION IN (MREN2)27 AND HANNOVER SPRAGUE DAWLEY RATS

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abstract
ABSTRACT The cardiovascular system is in a dynamic state with the ability to overcome stressors effectively, most importantly oxidative stress, and return to homeostasis. However, with age, a reduction in the ability to return to homeostasis results in several adaptive changes within the vessels as well as the heart. This process is accelerated by hypertension as a result of environmental or genetic factors. Furthermore, with regard to the cardiovascular system, males and females tend to age differently, however, the exact mechanisms are not well understood, in part due to the scarcity of using females in the experimental studies. Interventions to prevent or slow progression with aging are needed. Dietary polyphenols are natural plant derived compounds known to have anti-oxidant properties linked to beneficial cardiovascular effects. Nonetheless, knowledge of the long-term effects of dietary polyphenols in humans is limited.
subject
(mRen2)27 rats
Arterial stiffness
Cardiovascular aging
Hypertension
Muscadine Grape Extract
Sex differences
contributor
Ryalat, Fatima (author)
Diz, Debra DD (committee chair)
South, Andrew AS (committee member)
Yamaleyeva, Liliya LY (committee member)
Chappell, Mark MC (committee member)
date
2021-06-03T08:36:21Z (accessioned)
2021 (issued)
degree
Physiology and Pharmacology (discipline)
2026-05-17 (liftdate)
embargo
2026-05-17 (terms)
identifier
http://hdl.handle.net/10339/98842 (uri)
language
en (iso)
publisher
Wake Forest University
title
LONG-TERM EFFECT OF MUSCADINE GRAPE EXTRACT ON CARDIOVASCULAR FUNCTION IN (MREN2)27 AND HANNOVER SPRAGUE DAWLEY RATS
type
Dissertation

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