Item Details

title

Nitroaromatic Antibiotics as Nitrogen Oxide Sources

author

Rice, A.

author

Long, Y.

author

King, S.

abstract

Nitroaromatic antibiotics show activity against anaerobic bacteria and parasites, finding use in the treatment of Heliobacter pylori infections, tuberculosis, trichomoniasis, human African trypanosomiasis, Chagas disease and leishmaniasis. Despite this activity and a clear need for the development of new treatments for these conditions, the associated toxicity and lack of clear mechanisms of action have limited their therapeutic development. Nitroaromatic antibiotics require reductive bioactivation for activity and this reductive metabolism can convert the nitro group to nitric oxide (NO) or a related reactive nitrogen species (RNS). As nitric oxide plays important roles in the defensive immune response to bacterial infection through both signaling and redox-mediated pathways, defining controlled NO generation pathways from these antibiotics would allow the design of new therapeutics. This review focuses on the release of nitrogen oxide species from various nitroaromatic antibiotics to portend the increased ability for these compounds to positively impact infectious disease treatment.

subject

nitroaromatic antibiotics

nitric oxide

date

2021-08-23T14:57:11Z (accessioned)

2021-08-23T14:57:11Z (available)

2021-02-12 (issued)

identifier

Rice AM, Long Y, King SB. Nitroaromatic Antibiotics as Nitrogen Oxide Sources. Biomolecules. 2021; 11(2):267. https://doi.org/10.3390/biom11020267 (citation)

http://hdl.handle.net/10339/98978 (uri)

identifier

https://doi.org/10.3390/biom11020267 (doi)

language

en_US (iso)

publisher

MDPI

source

Biomolecules

type

Article