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THE CHARACTERIZATION OF BONE MARROW-DERIVED STEM CELL FACTOR AND ITS ROLE IN PROSTATE CANCER METASTASIS

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title
THE CHARACTERIZATION OF BONE MARROW-DERIVED STEM CELL FACTOR AND ITS ROLE IN PROSTATE CANCER METASTASIS
author
Foster, Brittni Meghan
abstract
BACKGROUND: About 1 in 8 men will be diagnosed with prostate cancer in their lifetime. Out of these men, 80% of advanced prostate cancer cases will develop metastases to the bone. There is currently no treatment for metastatic prostate cancer, only palliative treatment. Patients with bone metastases experience skeletal fractures, spinal cord compression, decreased mobility, and bone pain. Prior to metastasis, communication between the tumor and bone environment exists. Prostate cancer promotes osteoblastic activity causing bone formation to occur. CD117 and SCF have been shown to correlate with advanced prostate cancer, where the highest expression seen in the metastatic lesion. SCF has also been shown to increase in patients’ platelet releasates as prostate cancer progresses. SCF is expressed by both megakaryocytes, which produce platelets, and osteoblasts, which cause bone formation. Platelets and osteoblasts have been implicated in prostate cancer metastasis and the tumor to bone communication prior to metastatic lesion formation
subject
Bone Metastasis
Cancer Metastasis
CD117
Prostate Cancer
SCF
contributor
Kerr, Bethany (committee chair)
Almeida-Porada, Graca (committee member)
Shiozawa, Yusuke (committee member)
Bitting, Rhonda (committee member)
Peters, Chris (committee member)
date
2022-01-15T09:35:25Z (accessioned)
2022-07-14T08:30:13Z (available)
2021 (issued)
degree
Molecular Medicine and Translational Science (discipline)
embargo
2022-07-14 (terms)
identifier
http://hdl.handle.net/10339/99378 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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